Although the MOA of VUMERITY is unknown, its active metabolite (MMF) is an Nrf2 activator that increases antioxidant activity to defend against inflammation1-3

VUMERITY is a novel fumarate with a distinct chemical structure1,3

Nrf2 is expressed in every cell of the body including neurons and immune cells2

  • VUMERITY activates Nrf2 in the
    cell nucleus
  • It may reduce inflammatory activity caused by oxidative stress1-3

MMF (the active metabolite of VUMERITY) is believed to shift pro-inflammatory immune cells into an anti-inflammatory state4

The proposed MOA of VUMERITY suggests that it defends against oxidative stress1-3