Twice-Daily Dosing1

Starting Dose231 mg twice daily
(Days 1-7)

AM

pill

231 mg

PM

pill

231 mg

Maintenance Dose462 mg twice daily
(After Day 7)

AM

pill

462 mg

PM

pill

462 mg

For individuals who cannot tolerate the maintenance dose, a temporary dosage reduction to 231 mg twice a day may be considered

  • Within 4 weeks, the recommended dosage of 462 mg twice a day should be resumed
  • Discontinuation of VUMERITY should be considered for patients unable to tolerate return to the maintenance dosage 

Administration instructions

  • VUMERITY should be swallowed whole and intact
  • VUMERITY should not be crushed or chewed, and the capsule contents should not be sprinkled on food
  • If taken with food, a high-fat, high-calorie meal/snack should be avoided (the meal/snack should contain no more than 700 calories and no more than 30 g fat)
  • Avoid co-administration of VUMERITY with alcohol
  • No dosing adjustment is recommended in patients with mild renal impairment
  • VUMERITY is not recommended in patients with moderate or severe renal impairment

 

Speak to your patients about the importance of adherence when taking VUMERITY